Publication

Independent Publication

Coming soon!

Mentored Publications

19. Cao. Y.; Rodphon, W.; Alturaifi, T.; Lisboa, A.; Ren, Z.; Struijs, J.; Ni, H.-Q.; Savchuk, T.; Mykhailiuk, P.; Loach, R.; Yang, S.; McAlpine, I.; Blackmond, D.; Liu, P.; Sharpless, K. B.; Engle, K. M. Alkyl Sulfonyl Fluorides as Ambiphiles in the Stereoselective, Palladium (II)-Catalyzed Cyclopropanation of Unactivated Alkenes. ChemRxiv 2024, DOI: 10.26434/chemrxiv-2024-pdplt.

18. Ni, H.-Q.; Alturaifi, T.; Rodphon, W.; Scherschel. N. F.; Yang, S.; Wang, F.; McAlpine, I. J.; Piercey, D. G.; Liu, P.; Engle, K. M. Anti-Selective Cyclopropanation of Non-Conjugated Alkenes with Diverse Pronucleophiles via Directed Nucleopalladation, J. Am. Chem. Soc. 2024, 146, 24503–24514.

17. Ni, H.-Q.†; Dai, J.-C.†; Yang, S.; Loach, R. P.; Chuba, M. D.; McAlpine, I. J.; Engle, K. M. Catalytic σ-Bond Annulation with Ambiphilic Organohalides Enabled by β-X Elimination. Angew. Chem. Int. Ed. 2023, 62, e202306581. (†Authors contributed equally)

16. Ni, H.-Q.; Karunananda, M. K.; Zeng, T.; Yang, S.; Liu, Z.; Houk, K. N.; Liu, P.; Engle, K. M. Redox-Paired Alkene Difunctionalization Enables Skeletally Divergent Synthesis, J. Am. Chem. Soc. 2023, 145, 12351–12359.

15. Simlandy, A. K.; Rodphon, W.; Alturaifi, T. M.; Mai, B. K.; Ni, H.-Q.; Gurak, J. A., Jr.; Liu, P.; Engle, K. M. Catalytic Addition of Nitroalkanes to Unactivated Alkenes via Directed Carbopalladation. ACS Catal. 2022, 12, 13755–13762.

14. Ni, S.-X.; Li, Y.-L.; Ni, H.-Q.; Bi, Y.-X.; Sheng, J.; Wang, X.-S. Nickel-Catalyzed Hydromonofluoromethylation of Unactivated Alkenes for Expedient Construction of Primary Alkyl Fluorides. Chin. Chem. Lett. 2022, 40, 1531–1536.

13. Li, Z.-Q.; He, W.-J.; Ni, H.-Q.; Engle, K. M. Directed, Nickel-Catalyzed 1,2-Alkylsulfenylation of Alkenyl Carbonyl Compounds. Chem. Sci. 2022, 13, 6567–6572.

12. Liu, M.; Sun, J.; Erbay, T.; Ni, H.-Q.; Martín-Montero, R.; Liu, P.; Engle, K. M. Pd(II)-Catalyzed C(alkenyl)–H Activation Facilitated by a Transient Directing Group, Angew. Chem. Int. Ed.2022, 61, e202203624.

11. Ni, H.-Q.; Cooper, P.; Yang, S.; Wang, F.; Sach, N.; Bedekar, P. G.; Donaldson, J. S.; Tran-Dubé, M.; McAlpine, I. J.; Engle, K. M. Mapping Ambiphile Reactivity Patterns in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via Pd(II)/Pd(IV) Catalysis. Angew. Chem. Int. Ed. 2022, 61, e202114346.

10. Ni, H.-Q.†; Cooper, P.†; Engle, K. M. Recent Advances in Palladium-Catalyzed (Hetero)annulation of C=C Bonds with Ambiphilic Aryl (Pseudo)halides. Chem. Commun. 2021, 57, 7610–7624. (†Authors contributed equally)

9. Ni, H.-Q.; Li, Z.-Q.; Tran, V. T.; Engle, K. M. Modular Synthesis of Non-Conjugated N-(Quinolin-8-yl) Alkenyl Amides via Cross-Metathesis. Tetrahedron 2021, 93, 132279.

8. Sheng J.†; Ni, H.-Q.†; Ni, S.-X.; He, Y.; Cui, R.; Liao, G.-X.; Wu, B.-B.; Wang, X.-S. Diversity‐Oriented Synthesis of Aliphatic Fluorides via Reductive C(sp³)−C(sp³) Cross‐Coupling Fluoroalkylation. Angew. Chem. Int. Ed. 2021, 60, 15020–15027. (†Authors contributed equally)

7. Ni, H.-Q.; Kevlishvili, I.; Bedekar, P. G.; Barber, J. S.; Yang, S.; Tran-Dubé, M; Romine, A. M.; Lu, H.-X.; McAlpine, I. J.; Liu, P.; Engle, K. M. Anti-Selective [3+2] (Hetero)annulation of Nonconjugated Alkenes via Directed Nucleopalladation. Nat. Commun. 2020, 11,6432.

6. Li, H.; Sheng, J.; Liao, G.-X.; Wu, B.-B.; Ni, H.-Q.; Wang, X.-S. Nickel‐Catalyzed Direct Trifluoroethylation of Aryl Iodides with 1,1,1‐Trifluoro‐2‐Iodoethane via Reductive Coupling. Adv. Synth. Catal. 2020, 362, 5363–5367.

5. Wang, X.; Li, Z.-Q.; Mai, B. K.; Gurak, J. A., Jr.; Xu, J. E.; Tran, V. T.; Ni, H.-Q.; Liu, Z.; Liu, Z.; Yang, K. S.; Xiang, R.; Liu, P.; Engle, K. M. Controlling Cyclization Pathways in Palladium(II)-Catalyzed Intramolecular Alkene Hydrofunctionalization via Substrate Directivity. Chem. Sci., 2020, 11, 11307–11314.

4. Sheng, J.†; Ni, H.-Q.†; Zhang, H.-R.; Zhang, K.-F.; Wang, Y.-N.; Wang, X.-S. Nickel-Catalyzed Reductive Cross-coupling of Aryl Halides with Monofluoroalkyl Halides for Late-Stage Monofluoroalkylation. Angew. Chem., Int. Ed. 2018, 57, 7634−7639. (†Authors Contributed Equally)

3. Liu, Z.; Ni, H.-Q.; Zeng, T.; Engle, K. M. Catalytic Carbo- and Aminoboration of Alkenyl Carbonyl Compounds via Five- and Six-Membered Palladacycles. J. Am. Chem. Soc. 2018, 140, 3223–3227.

2. Sheng, J.; Ni, H.-Q.; Bian, K.-J.; Li, Y.; Wang, Y.-N.; Wang, X.-S. Nickel-Catalyzed Direct Difluoromethylation of Aryl Boronic Acids with BrCF₂H. Org. Chem. Front. 2018, 5, 606–610.

1. Sheng, J.; Ni, H.-Q.; Liu, G.; Li, Y.; Wang, X.-S. Combinatorial Nickel-Catalyzed Monofluoroalkylation of Aryl Boronic Acids with Unactivated Fluoroalkyl Iodides. Org. Lett. 2017, 19, 4480–4483.